No, it's a quirk of the player showing up as the best overall player who is not a starter for that week.
Because the player is an RB, he shows up as an offensive player of the week. But since he is a non-starter, and he was better than all the defenders that week, he also shows up on the "defensive" side.
"Upon further review, the ball boy handed officials a football filled with helium. The quarterback attempted to pitch the ball, striking the running back's helmet. The ball then continued to rise into the air, eventually crossing out of bounds. By rule, the ball will be spotted at the 17 where it exited the field of play and the ball boy is fired. Third down!"
